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Protomer A of WT Mpro is colored white and protomer B of WT Mpro is colored black, nirmatrelvir in WT Mpro-nirmatrelvir complicated composition is proven as eco-friendly sticks, protomer A of the mutant framework is colored marine and protomer B with the mutant structure is coloured orange, nirmatrelvir in mutant Mpro-nirmatrelvir complicated com